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February 22, 2026Medicine0 citationsOpen Access

Magnetic resonance imaging findings of non-mass enhancements in the breast and their association with malignancy

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FGFadime GüvenMÖMehmet Eren Öztürk

Key Points

  • The study aims to analyze the relationship between MRI features of non-mass enhancement lesions and malignancy.
  • Retrospective evaluation of 200 NME lesions using MRI findings.
  • Data collection included age, family history, lesion pathology, and follow-up durations.
  • Classification of lesions into benign, high-risk, and malignant based on follow-up and pathology results.
  • Statistical analysis was performed to assess the association between lesion groups and MRI features.
  • Segmental (48.4%) and diffuse (85.7%) patterns were linked to malignant lesions.
  • Clumped (51.5%) and clustered ring (100%) enhancements were significantly associated with malignancies.
  • A Type 3 time-intensity curve was observed in 84.6% of malignant cases.
  • Lesions with multiple curves indicated malignancy in 29.2% of cases.
  • Malignant and high-risk lesions exhibited significantly lower ADC values than benign lesions.

Abstract

Our aim is to investigate the relationship between the MRI (Magnetic Resonance Imaging) features of non-mass enhancement (NME) lesions and malignancy. MRI findings of 200 and 2 NME lesions were retrospectively evaluated. Age, family history of breast cancer, lesion pathology results, and follow-up durations of the patients were obtained from medical records. Based on follow-up findings and pathology results, the lesions were classified into 3 groups as benign, high-risk, and malignant. The association between these groups and MRI features was analyzed statistically. Segmental (48.4%) and diffuse (85.7%) distribution patterns, as well as clumped (51.5%) and clustered ring (100%) enhancement patterns of NME lesions, were found to be associated with malignant lesions. According to the time-intensity curve, a Type 3 curve was associated with malignant lesions in 84.6% of cases. When evaluating the number of dynamic curves, lesions with multiple curves were considered malignant in 29.2% of cases. Regarding apparent diffusion coefficient (ADC) values, malignant and high-risk lesions had significantly lower ADC values compared to benign lesions. In this study, segmental and diffuse distribution patterns, clumped and clustered ring enhancement, Type 3 curve, and low ADC values were found to be associated with malignant lesions.

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Cite This Study

Güven et al. (2026) studied this question.

synapsesocial.com/papers/699a9ded482488d673cd43c2https://doi.org/10.1097/md.0000000000047854
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