Background The mpox outbreak in 2022 posed a new challenge to the medical system. We aimed to study the impact of human immunodeficiency virus (HIV) coinfection on mpox patients. Methods This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results Our study included 27 articles for meta-analysis and divided mpox patients into two groups: one group was HIV-positive, and the other group was HIV-negative. We found that the age of HIV-positive patients was significantly greater than that of HIV-negative patients (SMD = 0.35, 95% CI: 0.29–0.41) and that there were more men who had sex with men in the HIV-positive group (OR = 3.98, 95% CI: 3.04–5.21). Syphilis (OR = 2.66, 95% CI: 2.13–3.33), hepatitis B (OR = 3.94, 95% CI: 2.93–5.30), hepatitis C (OR = 5.71, 95% CI: 3.06–10.64), proctitis (OR = 1.52, 95% CI: 1.17–1.98), fever (OR = 1.15, 95% CI: 1.01–1.30), diarrhea (OR = 1.69, 95% CI: 1.03–2.77) and pustules (OR = 1.33, 95% CI: 1.08–1.62) were more common among HIV-positive patients. HIV coinfection seemed to be associated with a decrease in the CD4 + T-cell count (SMD = −0.78, 95% CI: −1.34 to −0.23) and hemoglobin (SMD = −0.43, 95% CI: −0.64 to −0.22) and albumin (SMD = −0.35, 95% CI: −0.55 to −0.15) levels, whereas the CD8 + T-cell count yielded the opposite statistical conclusion (SMD = 0.35, 95% CI: 0.03–0.67). We also found that HIV-positive patients had more hospitalizations (OR = 1.63, 95% CI: 1.22–2.19), more severe mpox (OR = 1.82, 95% CI: 1.28–2.58), more need for tecovirimat treatment (OR = 4.25, 95% CI: 1.59–11.4), and higher mortality (OR = 3.36, 95% CI: 1.15–9.83). Conclusion Overall, HIV coinfection may influence the disease process and clinical indicators of mpox patients and is associated with more severe clinical outcomes. Systematic review registration https://www.crd.york.ac.uk/PROSPERO/view/CRD420251056729 , PROSPERO registration number: CRD420251056729.
Han et al. (2026) studied this question.