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February 23, 2026Scientia Sinica Vitae0 citationsOpen Access

Mechanistic Insights into ZKSCAN3-Mediated Regulation of Lysosome Biogenesis and pathogenesis of neurodegenerative diseases and cancer progression

YWYiqing WenNWNing WangCZChunmeng Zhao

Key Points

  • The study aims to understand how ZKSCAN3 regulates lysosome biogenesis and its impact on neurodegenerative diseases and cancer.
  • Investigated the role of ZKSCAN3 in lysosome biogenesis and gene expression regulation.
  • Examined subcellular localization and protein interactions of ZKSCAN3.
  • Analyzed post-translational modifications of ZKSCAN3.
  • ZKSCAN3 is essential for the transcriptional regulation of autophagy and lysosome-related genes.
  • Changes in ZKSCAN3's dimerization and modifications significantly influence lysosomal function.
  • Enhancing lysosome biogenesis potentially alleviates symptoms of neurodegenerative diseases and cancer.

Abstract

溶酶体（Lysosome）是负责细胞内物质降解与稳态调控的重要细胞器，它与内体、自噬体、线粒体等协同工作，承担胞内蛋白质、糖类、脂类及核酸等大分子的降解与循环利用。溶酶体功能受损诱发并加重溶酶体贮积病、神经退行性疾病、和代谢疾病等。但促进溶酶体生成并增强溶酶体降解功能可以清除治病底物，进而改善相关疾病。ZKSCAN3（Zinc Finger With KRAB And SCAN Domains 3；ZNF306）是调控溶酶体生成的重要蛋白，做为含有SCAN与KRAB结构域的锌指转录抑制因子，在转录水平上调控自噬与溶酶体相关基因的表达。ZKSCAN3亚细胞定位、生物活性、和蛋白水平的变化（二聚体和翻译后修饰）影响靶基因的转录调控，进而影响生理条件下的稳态调控和病理条件下的疾病发生发展。

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Cite This Study

Wen et al. (2026) studied this question.

synapsesocial.com/papers/699bee1c1c6c6bad5397fe65https://doi.org/10.1360/ssv-2025-0332
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Also Consider

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