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February 24, 2026Cureus0 citationsOpen Access

Pheochromocytoma Crisis Presenting as Cardiac Arrest and Reversible Cardiomyopathy in a Young Adult: A Case Report

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EGEugeniu GiscaRDRui B DiasCSCatia R Santos

Key Result

Intensive care support with alpha-adrenergic blockade and surgical resection led to complete recovery of myocardial function and survival in a 32-year-old man presenting with pheochromocytoma crisis causing cardiac arrest and cardiomyopathy.

Key Points

  • To present a case of acute cardiac complications due to pheochromocytoma in a young adult.
  • Reported a case of a 32-year-old man with cardiac arrest and severe myocardial dysfunction.
  • Evaluated the patient with CT imaging to identify adrenal masses and biochemical testing for catecholamines.
  • Provided intensive care management including mechanical ventilation and vasoactive support.
  • The patient exhibited severe biventricular dysfunction and elevated cardiac biomarkers.
  • CT scan revealed a large right adrenal mass suggestive of pheochromocytoma.
  • Biochemical tests confirmed elevated catecholamines and metanephrines, indicating a pheochromocytoma diagnosis.
  • After treatment, there was a progressive recovery in myocardial function.
  • The patient was referred for surgical management following stabilization.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
32-year-old man with no known past medical history or previously diagnosed cardiovascular disease presenting with acute respiratory distress, hemodynamic instability, and cardiac arrest.
I
Intervention
Intensive care support (invasive mechanical ventilation, vasopressor and inotropic therapy), empiric antibiotics, alpha-adrenergic blockade (doxazosin 4 mg once daily), and elective surgical resection of the adrenal tumor.
O
Outcome
Clinical recovery and recovery of biventricular systolic function.

Pheochromocytoma crisis is a rare but reversible cause of cardiac arrest and acute cardiomyopathy in young adults that requires early recognition and coordinated multidisciplinary management.

Limitations

  • Single patient case report without control group
  • Findings may not be generalizable to broader populations
  • No quantitative effect size or statistical comparison possible

Abstract

Acute circulatory collapse and severe myocardial dysfunction in young adults without prior cardiovascular disease represent a critical diagnostic challenge in emergency and intensive care settings. We report the case of a 32-year-old man who presented to the emergency department with acute respiratory failure, profound metabolic acidosis, and hemodynamic instability, rapidly progressing to cardiac arrest with the return of spontaneous circulation. Initial evaluation revealed severe biventricular dysfunction and markedly elevated cardiac biomarkers. CT identified a large right adrenal mass suggestive of pheochromocytoma. Biochemical testing later confirmed markedly elevated plasma and urinary catecholamines and metanephrines. The patient required invasive mechanical ventilation, vasoactive support, and advanced intensive care management. Progressive recovery of myocardial function was observed following stabilization and targeted medical therapy, supporting the diagnosis of catecholamine-induced cardiomyopathy. He was subsequently referred for endocrine follow-up and definitive surgical management. This case highlights pheochromocytoma crisis as a rare but reversible cause of cardiac arrest and acute cardiomyopathy in young adults. Early recognition and coordinated intensive care and endocrine management are crucial to improve outcomes in this potentially fatal condition.

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Cite This Study

Gisca et al. (2026) conducted a case report in Pheochromocytoma crisis presenting as cardiac arrest and reversible cardiomyopathy (n=1). Intensive care support including invasive mechanical ventilation, vasopressor/inotropic therapy, alpha-adrenergic blockade (doxazosin), and elective surgical resection of adrenal tumor was evaluated on Recovery of myocardial function and survival after pheochromocytoma crisis with cardiac arrest. Intensive care support with alpha-adrenergic blockade and surgical resection led to complete recovery of myocardial function and survival in a 32-year-old man presenting with pheochromocytoma crisis causing cardiac arrest and cardiomyopathy.

synapsesocial.com/papers/699d3f9ede8e28729cf643f4https://doi.org/10.7759/cureus.104024
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