Abstract INTRODUCTION This study examined whether performance on the web‐based Latin American Spanish Face–Name Associative Memory Exam (LAS‐FNAME), an associative memory test, is associated with plasma biomarkers in autosomal dominant Alzheimer's disease (ADAD). METHODS One hundred sixty‐one members from the Colombian kindred with presenilin‐1 ( PSEN1 ) E280A mutation (61 cognitively unimpaired carriers, 22 cognitively impaired carriers, and 78 non‐carriers), completed the web‐based LAS‐FNAME and provided blood samples for biomarker analysis. Analysis of covariance was used to compare LAS‐FNAME performance among groups and Spearman correlations to examine its associations with levels of plasma phosphorylated tau (p‐tau)217, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP). RESULTS Carriers had lower LAS‐FNAME performance (P < 0.001) and higher p‐tau217 (P < 0.001), NfL (P = 0.013), and GFAP (P < 0.001) levels than non‐carriers. Higher p‐tau217, NfL, and GFAP were associated with worse LAS‐FNAME performance, controlling for age, sex, and education. DISCUSSION The web‐based LAS‐FNAME is a promising tool for detecting early memory decline in AD, warranting future studies to evaluate its longitudinal utility. Highlights The web‐based Latin American Spanish Face–Name Associative Memory Exam (LAS‐FNAME) detects memory decline in presenilin 1 ( PSEN1 ) mutation carriers. LAS‐FNAME scores correlate with blood biomarkers in PSEN1 carriers. The web‐based format enables remote assessment via participants’ personal devices. The study was conducted in Spanish‐speaking adults at risk for dementia. Findings support combined use of digital cognitive tools and blood biomarkers.
Corona et al. (2026) studied this question.