Malignant melanoma is a neoplasm originating from melanocytes and may arise at cutaneous or extracutaneous sites. Penile involvement is uncommon and may present with variable clinical manifestations. We describe a case of a 47-year-old male who presented with a progressively enlarging lesion involving the glans penis, initially associated with pruritus and later with severe local pain and bilateral inguinal lymphadenopathy. Histopathological examination of an incisional biopsy confirmed malignant melanoma of the penis. Imaging studies performed for staging demonstrated regional lymph node involvement and disseminated visceral disease. The patient underwent surgical management followed by systemic treatment after multidisciplinary evaluation. This case illustrates the clinical presentation, diagnostic approach, and management of penile malignant melanoma.
Guarda et al. (2026) studied this question.