PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
February 25, 2026AIDS1 citations

Changes in cardiovascular and metabolic risk scores after switching to DOR/3TC/TDF, DTG/3TC or BIC/FTC/TAF: results from a multicenter Italian cohort

View Full Paper
EZEnea ZiniVIValentina IannoneAGAndrea Giacomelli

Key Result

Switching to DOR/3TC/TDF led to more favorable changes in cardiovascular (SCORE-2) and metabolic (METS-IR) risk scores than DTG/3TC or BIC/FTC/TAF in an Italian cohort.

Key Points

  • This research aims to compare changes in cardiovascular and metabolic risk scores after switching antiretroviral treatments.
  • Multicenter cohort study
  • Participants switched to DOR/3TC/TDF, DTG/3TC, or BIC/FTC/TAF
  • Evaluated changes in SCORE-2 and METS-IR scores
  • Switching to DOR/3TC/TDF led to more favorable changes in SCORE-2 and METS-IR scores
  • DTG/3TC and BIC/FTC/TAF showed less improvement in these scores

Structured PICO

Does switching to DOR/3TC/TDF improve SCORE-2 and METS-IR compared to DTG/3TC and BIC/FTC/TAF in a multicenter Italian cohort?

P
Population
Multicenter Italian cohort
I
Intervention
Switching to DOR/3TC/TDF
C
Comparator
DTG/3TC and BIC/FTC/TAF
O
Outcome
Changes in SCORE-2 and METS-IRsurrogate

Switching to DOR/3TC/TDF is associated with more favorable changes in cardiovascular and metabolic risk scores compared to other common antiretroviral regimens.

Abstract

We found that switching to DOR/3TC/TDF was associated with more favorable changes in SCORE-2 and METS-IR compared to DTG/3TC and BIC/FTC/TAF.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Zini et al. (2026) studied this question. Switching to DOR/3TC/TDF led to more favorable changes in cardiovascular (SCORE-2) and metabolic (METS-IR) risk scores than DTG/3TC or BIC/FTC/TAF in an Italian cohort.

synapsesocial.com/papers/699e90eff5123be5ed04e300https://doi.org/10.1097/qad.0000000000004468
Ask AI
Helpful
Bookmark
Share
View Full Paper