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February 25, 2026Modern Rheumatology0 citations

Cortical Bone Defects at MCP and Wrist Joints in Healthy Individuals assessed by HR-pQCT

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TITakeshi IidaUniversity of NagasakiKCK. ChibaUniversity of NagasakiKSKazuteru ShiraishiUniversity of Nagasaki

Key Points

  • This research aimed to assess the presence of cortical bone defects in the MCP and wrist joints of healthy individuals.
  • High-resolution peripheral quantitative computed tomography (HR-pQCT) was used for imaging.
  • Bone erosions were measured in both MCP and wrist joints.
  • The relationship between the size of erosions and age was analyzed.
  • Well-defined erosions of ≥0.5 mm3 were frequently observed in the capitate and lunate bones.
  • Smaller erosions (<0.5 mm3) showed a positive correlation with age.
  • Findings suggest that many small bone defects may indicate normal aging rather than disease.

Abstract

Numerous bone erosions were identified in the MCP and wrist joints of healthy individuals. Relatively well-defined erosions measuring ≥0.5 mm3 were frequently observed in specific carpal bones, particularly the capitate and lunate. Additionally, erosions smaller than 0.5 mm3 showed a positive correlation with age, suggesting that numerous small cortical bone defects may represent age-related physiological changes. These findings provide important context when interpreting erosive changes associated with joint diseases in clinical practice.

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Cite This Study

Iida et al. (2026) studied this question.

synapsesocial.com/papers/699e912ef5123be5ed04e798https://doi.org/10.1093/mr/roag016
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