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February 25, 20260 citations

Secondary poor graft function after autologous stem cell transplantation in multiple myeloma: a case-based expert review and successful rescue with secondary autologous stem cell infusion.

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JYJiawen YouYZYuanyuan ZhangYMYuan Meng

Key Points

  • The review aims to explore the causes and solutions for secondary poor graft function after autologous stem cell transplantation in multiple myeloma.
  • Expert analysis of case reports on secondary PGF after Auto-HSCT.
  • Identification of factors contributing to PGF and assessment of potential interventions.
  • Evaluation of the efficacy of secondary autologous PBSC infusion as a rescue strategy.
  • Identified multiple factors causing secondary poor graft function, including graft quality issues and therapy exposure.
  • Early unpreconditioned autologous PBSC boost found to be safe and feasible.
  • Strategic banking of PBSC identified as crucial for preventing life-threatening graft failures.

Abstract

Secondary PGF after Auto-HSCT appears multifactorial, involving quantitatively adequate but qualitatively fragile grafts, inflammatory/microenvironmental injury, and therapy-related megakaryocytic vulnerability (including heavy lenalidomide exposure). When backup cells are available and reversible causes are excluded, early unpreconditioned autologous PBSC boost is a safe, feasible, and likely under-utilized salvage strategy. Strategic PBSC banking and early recognition may prevent life-threatening PGF.

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Cite This Study

You et al. (2026) studied this question.

synapsesocial.com/papers/699e9152f5123be5ed04ebfdhttps://doi.org/10.1080/16078454.2026.2633462
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