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February 26, 2026International Journal of Social Determinants of Health and Health Services4 citationsOpen Access

From Averages to Heterogeneity: A Plain-Language Guide to MAIHDA in Epidemiology

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JMJuan MerloJKJay S. KaufmanGLGeorge B Leckie

Key Points

  • The research aims to explain how MAIHDA can clarify health differences by focusing on individual variations rather than just averages.
  • Introduced the MAIHDA framework to analyze health disparities.
  • Integrated specific and general contextual effects along with discriminatory accuracy.
  • Emphasized the importance of multilevel analysis in understanding individual inequalities.
  • Demonstrated that averages can be misleading in health comparisons.
  • Highlighted how context significantly shapes health outcomes and individual differences.
  • Provided insights into whether health interventions should be universal or targeted.

Abstract

Many studies compare health averages between groups such as neighbourhoods or social categories. Averages are simple but can be misleading, since individuals within the same group often differ widely. We present MAIHDA (Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy) as a general framework to study how context structures health differences. MAIHDA is not a new statistical model but a way to reorganize standard multilevel analysis to look beyond averages. It integrates three perspectives: (1) Specific Contextual Effects (mean differences between groups), (2) General Contextual Effects (how strongly outcomes cluster within groups, eg the variance partition coefficient), and (3) Discriminatory Accuracy (how well group membership classifies individuals according to the outcome). Interpreting these dimensions together shows to which degree a context shapes outcome and whether interventions should be universal or targeted. Although intersectional studies have recently popularized MAIHDA, the framework predates its intersectional applications. It was first developed within contextual epidemiology to study geographical and institutional settings, and later extended to intersectionality and multicategorical analyses, which added visibility. By shifting attention from averages to heterogeneity and clustering, MAIHDA helps avoid group stigmatization and guides equitable strategies such as proportionate universalism. It offers a practical, theory-agnostic way to understand how contexts structure individual inequalities.

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Cite This Study

Merlo et al. (2026) studied this question.

synapsesocial.com/papers/699fe32295ddcd3a253e6b94https://doi.org/10.1177/27551938261423042
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