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Synapse
February 26, 20260 citations

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression.

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LXLi-Mei XiaoQZQ. ZhaoRLRunhua Li

Key Points

  • This research aims to explore how changes in the immune system contribute to the progression of multiple sclerosis (MS).
  • Analysis of the H3.3<sup>low</sup>/ERE<sup>high</sup> signature in MS and post-COVID-19 conditions.
  • Investigation of the link between infections and innate immune changes in MS.
  • Found a connection between skewed myelopoiesis and the immune changes observed in MS.
  • Identified the H3.3<sup>low</sup>/ERE<sup>high</sup> signature as a potential target for therapeutic intervention.

Abstract

The H3.3low/EREhigh signature may not only explain the common skewed myelopoiesis in MS and post-COVID-19 conditions, but also provide a mechanistic link between infection and the innate immune reprogramming that drives MS progression. This offers a novel therapeutic insight for MS.

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Cite This Study

Xiao et al. (2026) studied this question.

synapsesocial.com/papers/699fe33695ddcd3a253e6e4fhttps://doi.org/10.1002/acn3.70350
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1From emergency myelopoiesis to chronic myeloid reprogramming: hematopoietic dysregulation in multiple sclerosis2026
  2. 2Human endogenous retrovirus W in multiple sclerosis: transcriptional activity is associated with decline in oligodendrocyte proportions in the white matter of the brain2024 · 2 citations
  3. 3Genomic analysis of ERVWE2 locus in patients with multiple sclerosis: absence of genetic association but potential role of human endogenous retrovirus type W elements in molecular mimicry with myelin antigen2013 · 44 citations
  4. 4Do Human Endogenous Retroviruses Contribute to Multiple Sclerosis, and if So, How?2018 · 58 citations
  5. 5EBV Dysregulation Is Associated With Immune Imbalance in Multiple Sclerosis2026 · 1 citations