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February 26, 2026RSC Advances0 citationsOpen Access

Piperazine-grafted magnetic graphene oxide as a sustainable heterogeneous catalyst for solvent-free Biginelli reaction

ERE. Rezaei-SereshtFJFaezeh JalambadaniSCSamira Cheshak

Key Points

  • This research aims to explore the effectiveness of piperazine-grafted magnetic graphene oxide as a catalyst in the Biginelli reaction.
  • Developed a piperazine-grafted magnetic graphene oxide catalyst.
  • Conducted solvent-free Biginelli reaction for synthesizing dihydropyrimidine-2-ones.
  • Analyzed reaction efficiency and product yield.
  • Demonstrated high catalytic activity in the Biginelli reaction.
  • Achieved significant yield of dihydropyrimidine-2-ones without solvents.

Abstract

Biginelli reaction is a powerful tool for the one-pot synthesis of complex organic compounds, due to its versatility in synthesizing a wide range of dihydropyrimidine-2-ones (DHPMs) with diverse biological activities.

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Cite This Study

Rezaei-Seresht et al. (2026) studied this question.

synapsesocial.com/papers/699fe38b95ddcd3a253e7795https://doi.org/10.1039/d5ra05063d
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