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Synapse
February 26, 2026Communications Medicine0 citationsOpen Access

Hormonal contraceptives and EEG biomarkers for antidepressant treatment response in women

KJK. H. R. JensenAJA. K. JuvikSLS. V. Larsen

Key Points

  • The research aims to explore how hormonal contraceptives influence EEG biomarkers and antidepressant treatment outcomes in women with major depressive disorder (MDD).
  • Analyzed the relationship between hormonal contraceptive use and EEG biomarkers in unmedicated depressed women.
  • Evaluated treatment responses to antidepressants in women using combined oral contraceptives (COC).
  • Investigated the modulation of EEG biomarkers linked to antidepressant response by contraceptive use.
  • Findings indicate no direct association between hormonal contraceptives and EEG biomarkers in unmedicated women.
  • However, COC users displayed poorer antidepressant treatment outcomes compared to non-users.
  • The study highlights potential for EEG-based biomarkers in guiding treatment strategies for women with MDD.

Abstract

Although hormonal contraceptive use is not associated with EEG-biomarkers in unmedicated depressed women, they may modulate links between specific EEG-biomarkers and antidepressant response. However, contraceptive use, specifically COC, is associated with worse treatment outcomes and may be critical to developing biomarkers, including EEG-based, to guide treatment in women with MDD.

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Cite This Study

Jensen et al. (2026) studied this question.

synapsesocial.com/papers/699fe39d95ddcd3a253e7978https://doi.org/10.1038/s43856-026-01438-4
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