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February 27, 2026Current BiologyOpen Access

Evolution of the vertebrate retina by repurposing of a composite ancestral median eye

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Authors

GKGeorge KafetzisMBMichael J. BokTBTom Baden

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Overview

Research demonstrates the evolution of retinal structures in chordates, highlighting an integration of photoreceptor circuits.

Key Points

  • The aim is to uncover how the vertebrate retina evolved from an ancestral median eye structure.
  • Analysis of the structure and function of vertebrate retinas and ancestral median eyes.
  • Comparative studies of photoreceptor types and their origins.
  • Examination of evolutionary pathways linking early chordates to modern vertebrates.
  • Identified a shift from median to lateralized photoreceptive structures in vertebrates.
  • Established that bipolar cells have dual evolutionary origins from both ciliary and rhabdomeric lineages.
  • Highlighted key similarities between the vertebrate retina and the pineal gland, suggesting an integrated evolution of sensory circuits.

Cite This Study

Kafetzis et al. (2026) studied this question.

synapsesocial.com/papers/69a1344fed1d949a99abe06ahttps://doi.org/10.1016/j.cub.2025.12.028
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