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Synapse
February 27, 20260 citations

WuYeLuGen Granule Attenuates Bleomycin-Induced Pulmonary Fibrosis in Rats by Inhibiting the TGF-β1/Smad Signaling Pathway and Epithelial-Mesenchymal Transition.

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JZJia-Wei ZengLLLi LinYDYan-Jun Duan

Key Points

  • The study aims to evaluate the effects of WuYeLuGen Granule on pulmonary fibrosis and its underlying mechanisms.
  • Utilized rat models to assess pulmonary fibrosis
  • Administered WuYeLuGen Granule
  • Analyzed the TGF-β1/Smad signaling pathway
  • Examined epithelial-to-mesenchymal transition in lung tissue
  • WYLG significantly reduced fibrosis markers in rat lungs
  • Inhibition of TGF-β1/Smad pathway was confirmed
  • Epithelial-to-mesenchymal transition was suppressed, indicating improved lung function

Abstract

WYLG markedly alleviates pulmonary fibrosis both in vivo and in vitro by inhibiting the TGF-β1/Smad signaling pathway and regulating epithelial-to-mesenchymal transition, highlighting its potential as a therapeutic agent for progressive pulmonary fibrosis.

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Cite This Study

Zeng et al. (2026) studied this question.

synapsesocial.com/papers/69a1353eed1d949a99abefedhttps://doi.org/10.1155/carj/8103859
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