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February 27, 20260 citationsOpen Access

NODESINNDIANAD2. 7Fructose alters duodenal Mucin glycosylation in high-fat diet-fed mice

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DMDonatella MentinoMFMaria Felicia FaienzaFPFlavia Prodam

Key Points

  • To determine how fructose supplementation affects mucin composition in the duodenum of mice on a high-fat diet, considering age differences.
  • Used young and adult mice for comparison
  • Administered normal diet, high-fat diet, or high-fat diet plus fructose
  • Analyzed Brunner’s glands and villus goblet cells
  • Utilized histochemistry and lectin profiling to assess mucins
  • Conducted the study over a 16-week period
  • Fructose supplementation altered mucin glycosylation in mice on high-fat diets
  • Changes observed in both young and adult mice
  • Impacts on the intestinal mucosal barrier were noted according to age
  • Specific alterations in mucin production were linked to fructose intake

Abstract

Fructose, a major component of modern diets, is strongly associated with pediatric obesity and metabolic syndrome, yet its direct effects on the intestinal mucosal barrier and mucin composition remain poorly defined. We investigated whether fructose supplementation alters high-fat diet (HFD)–induced changes in duodenal mucins in an age-dependent manner. Young and adult mice were fed a normal diet (ND), HFD, or HFD plus 30% fructose in drinking water (HFD+Fru) for 16 weeks. Brunner’s glands and villus goblet cells were analyzed by histochemistry and lectin profiling to assess mucin production and O-glycosylation.

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Cite This Study

Mentino et al. (2026) studied this question.

synapsesocial.com/papers/69a13550ed1d949a99abf041https://doi.org/10.5281/zenodo.18768818
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dietary Fructose Alters Duodenal Mucin Glycosylation and Mucus Production in High-Fat Diet-Fed Mice2026
  2. 2Investigating the role of the gut in fructose induced glucose intolerance2024
  3. 3Effects of replacing dietary glucose with fructose on intestinal morphology, oxidative status, and epithelial responses in weaned pigs2026
  4. 4Fructose Overconsumption Aggravates Intestinal Inflammation and Gut Dysbiosis in a Mouse Model of Allergic Asthma 90772025
  5. 5Study of the Behavioral Pattern in Type-2 Diabetic Mice Prepared by Introducing 10% and 15% Fructose Solution2024