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February 27, 20260 citations

Identification of Ferroptosis-Related Hub Genes and Immune Infiltration Landscape in Chronic Kidney Disease via Bioinformatics and Experimental Verification.

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YLYong LuoZHZhong-Ying HuangJYJifang Yang

Key Points

  • This research aims to identify hub genes related to ferroptosis and their role in chronic kidney disease (CKD).
  • Used bioinformatics to analyze gene expression data related to CKD.
  • Conducted experimental verification of identified biomarkers.
  • Examined immune infiltration profiles associated with CKD progression.
  • Identified NNMT, GDF15, ACSL1, DLD, NFE2L2, PARP1, and NR4A1 as significantly upregulated in CKD.
  • Suggested potential of these biomarkers for CKD diagnosis and treatment.

Abstract

Our study confirms NNMT, GDF15, ACSL1, DLD, NFE2L2, PARP1, and NR4A1 as significantly upregulated biomarkers associated with ferroptosis in CKD progression, suggesting their potential as novel targets for CKD diagnosis and treatment.

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Cite This Study

Luo et al. (2026) studied this question.

synapsesocial.com/papers/69a13550ed1d949a99abf123https://doi.org/10.1002/iid3.70391
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