Effect of modulation of alimentary and formulation pH on the pharmacokinetics of BCS-Class I, II, III, and IV compounds in rats following cassette dosing.

Key Points

• This research examines how the pH of the alimentary canal and formulations affects the pharmacokinetics of different drug compounds.
• Conducted experiments on rats using cassette dosing approaches.
• Analyzed the effects of varying pH levels in the alimentary canal and formulations.
• Measured pharmacokinetic responses based on different BCS-class drug compounds.
• Both acidic and basic pH conditions significantly influence pharmacokinetics.
• Effects are observed in relation to the acid dissociation constant pKa of compounds.
• Pharmacokinetic variations occur independently of the compound's salt form.