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February 27, 2026JAMA Psychiatry0 citations

A Developmentally Informed Study of Sleep and Circadian Polygenic Scores in Adolescence

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KLKatie J. S. LewisJMJean MartinJHJon Heron

Key Points

  • The study aims to explore the genetic connections between sleep and circadian rhythms in adolescents and adults.
  • Analyzed genetic data related to sleep and circadian rhythms.
  • Examined correlations between sleep and circadian phenotypes across different age groups.
  • Suggested future studies should include larger genome-wide association studies (GWAS) across developmental stages.
  • Identified overlaps in genetic factors influencing sleep and circadian traits between adolescence and adulthood.
  • Highlighted the need for further genome studies to understand these genetic influences and their variations over time.

Abstract

Results of this study suggest overlap in the genetic etiology of sleep and circadian phenotypes in adolescence and adulthood. This has importance for studies using genomic designs for causal inference about sleep and understanding of the extent to which genetic influences vary across the lifespan. Future research, including larger GWAS across developmental periods, is required to further understand genetic influences on sleep across the lifespan, as well as environmental influences on adolescent sleep disturbances.

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Cite This Study

Lewis et al. (2026) studied this question.

synapsesocial.com/papers/69a1357fed1d949a99abf703https://doi.org/10.1001/jamapsychiatry.2025.4647
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