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February 27, 2026European Journal of Preventive Cardiology2 citationsOpen Access

Vascular Health After Quitting Smoking or Switching to E-Cigarette Use: A Systematic Review of Prospective Studies with GRADE Assessment

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JGJacob GeorgeAmrita Institute of Medical Sciences and Research CentreGRGiusy Rita Maria La RosaUniversity of CataniaJYJacqueline YuUniversity of Dundee

Key Result

Smoking cessation improves vascular function by positively affecting endothelial and arterial stiffness markers, though evidence certainty ranges from moderate to very low.

Key Points

  • The research aims to assess how quitting smoking or switching to e-cigarettes affects vascular health.
  • Conducted a systematic review of prospective studies on vascular function after smoking cessation or e-cigarette use.
  • Evaluated endpoints like endothelial function and arterial stiffness markers.
  • Assessed the quality of evidence using GRADE framework.
  • Smoking cessation shows early improvements in vascular function indicators.
  • Positive changes are noted in endothelial and arterial stiffness markers.
  • The certainty of findings varies from moderate to very low.

Structured PICO

Does smoking cessation or switching to e-cigarette use improve vascular function?

P
Population
Individuals quitting smoking or switching to e-cigarette use
I
Intervention
Smoking cessation or switching to e-cigarette use
O
Outcome
Vascular function (endothelial and arterial stiffness markers)surrogate

Smoking cessation improves vascular function markers, supporting the cardiovascular benefits of sustained abstinence.

Limitations

  • overall certainty varies from moderate to very low

Abstract

Smoking cessation appears to improve vascular function, as reflected by early favorable changes in endothelial and arterial stiffness markers; however, the overall certainty varies from moderate to very low, according to the outcome. These findings are consistent with the biological plausibility of cardiovascular benefit from sustained smoking abstinence.

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Cite This Study

George et al. (2026) studied this question. Smoking cessation improves vascular function by positively affecting endothelial and arterial stiffness markers, though evidence certainty ranges from moderate to very low.

synapsesocial.com/papers/69a13591ed1d949a99abf8e4https://doi.org/10.1093/eurjpc/zwag123
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