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February 28, 2026Critical Care Science0 citationsOpen Access

Secondary infections in the intensive care unit do not worsen long-term functional outcomes in sepsis survivors

TCTaciana de Castilhos CavalcantiMMMiriane Melo Silveira MorettiCTCassiano Teixeira

Key Points

  • To investigate if secondary infections during ICU stay affect long-term functional outcomes in sepsis survivors.
  • Observational study design
  • Analysis of patients with sepsis in the ICU
  • Assessment of secondary infections during ICU stay
  • Evaluation of long-term functional outcomes post-discharge
  • Secondary infections did not worsen long-term functional outcomes in sepsis survivors
  • No significant differences in disability measures between patients with and without secondary infections
  • Findings suggest that other factors may play a larger role in long-term recovery

Abstract

Sepsis often triggers a cascade of immunosuppressive events that can leave patients vulnerable to secondary infections during their intensive care unit (ICU) stay.() These infections – most commonly pneumonia, bloodstream, and urinary tract infections – are thought to worsen both short- and long-term outcomes. However, whether ICU-acquired infections contribute to persistent functional disability in survivors …

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Cite This Study

Cavalcanti et al. (2026) studied this question.

synapsesocial.com/papers/69a285da0a974eb0d3c00c08https://doi.org/10.62675/2965-2774.20260247
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)2016 · 28,810 citations
  2. 2Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis2016 · 555 citations
  3. 3Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis2010 · 2,612 citations
  4. 4Sepsis and Septic Shock2024 · 370 citations
  5. 5Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy2013 · 2,740 citations