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February 28, 2026BMJ Case Reports0 citations

Neurosyphilis presenting with mesial temporal encephalitis and Argyll Robertson pupils: a diagnostic clue in the modern era

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BNBinh T. NguyenHNHuong Van NguyenVLVan Thuy Le

Key Points

  • To highlight the presentation of neurosyphilis with distinctive symptoms and evaluate diagnostic implications.
  • Clinical assessment of a male patient with confusion and cognitive decline.
  • Administration of the Montreal Cognitive Assessment (MoCA) during evaluation.
  • Observation of neurological signs including Argyll Robertson pupils.
  • Patient presented with confusion, amnesia, and disorientation.
  • Distinctive Argyll Robertson pupils noted.
  • Findings raise awareness of neurosyphilis as a diagnostic consideration in encephalitis.

Abstract

A man in his late 40s with no significant medical history was admitted after 3 weeks of progressive confusion, anterograde amnesia, misidentification of family members and recurrent panic episodes. On admission, he was disoriented to time and place, with a Montreal Cognitive Assessment (MoCA)

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Cite This Study

Nguyen et al. (2026) studied this question.

synapsesocial.com/papers/69a286240a974eb0d3c00e23https://doi.org/10.1136/bcr-2025-269885
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