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Synapse
February 28, 2026Nature0 citationsOpen Access

Parkinson’s disease affects network of brain regions that controls whole-body action

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Key Points

  • This research aims to explore how Parkinson's disease impacts brain networks involved in controlling whole-body actions.
  • Utilized precision brain imaging techniques on individuals with Parkinson's disease
  • Characterized the somato-cognitive action network connectivity
  • Assessed the effects of pharmacological and brain-stimulation therapies
  • Identified abnormally high connectivity in the somato-cognitive action network associated with Parkinson's disease
  • Noted normalization of connectivity with effective treatments
  • Established significant interactions with deep brain structures in affected individuals

Abstract

Precision brain imaging of individuals with Parkinson’s disease reveals that the affected circuit is best characterized as a previously described network of brain regions called the somato-cognitive action network. Abnormally high connectivity in this network is associated with Parkinson’s disease and is normalized by effective pharmacological treatment and various brain-stimulation therapies. A network called SCAN shows abnormally high connectivity with deep brain structures in people with Parkinson’s disease.

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Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/69a286240a974eb0d3c00e70https://doi.org/10.1038/d41586-026-00573-1
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