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February 28, 2026Microbiology

Side Tail Fibers of Phage Lambda₂B8 Do Not Bind BamA Receptor

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Authors

AKA. S. KuznetsovDBD. D. BarbashinSDS. A. Datskaia

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Overview

This investigation reveals that side tail fibers do not specifically bind to the BamA receptor in bacteria, suggesting alternative binding mechanisms.

Key Points

  • The study aims to investigate the binding mechanism of phage λ_2B8's side tail fibers to the BamA receptor in E. coli.
  • Genetic modification of phage λ_2B8 to create λ_2B8Jλ, replacing the central tail fiber protein gpJ
  • Transmission electron microscopy to visualize phage morphology and tail fibers
  • Analysis of adsorption kinetics on E. coli strains differing in BamA sequence.
  • No statistically significant difference in the adsorption rates of λ_2B8Jλ on different E. coli strains
  • Evidence suggests that the side tail fibers do not bind specifically to BamA
  • Indicates that another component of the phage virion likely interacts with the BamA receptor.

Cite This Study

Kuznetsov et al. (2025) studied this question.

synapsesocial.com/papers/69a286a70a974eb0d3c01bd6https://doi.org/10.1134/s0026261725604324
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