Levothyroxine mitigates autism-related behaviours in the maternally separated male mice possibly through manipulating hippocampal nitrite imbalance and neuroinflammation.

Key Points

• This research aims to explore how levothyroxine affects autism-related behaviours in maternally separated male mice.
• Examined the effect of levothyroxine in male mice that were subjected to maternal separation.
• Analyzed changes in hippocampal nitrite levels and neuroinflammation markers.
• Assessed behaviour changes related to autism symptoms.
• Levothyroxine treatment reduced autism-related behaviours in the mice.
• There was a noted improvement in the balance of nitrite in the hippocampus.
• Neuroinflammation levels decreased following levothyroxine administration.