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February 28, 2026Biomedicines0 citationsOpen Access

The Role of Experimental Animal Models in Liver Transplantation Training Programs

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MEMohamed El-ShobariMRM. Gamil RamadanTMTarek Mahdi

Key Points

  • To explore the importance of animal models in liver transplantation training programs and their contributions to skill development.
  • Critically synthesize literature from 1990 to 2024 related to training in liver transplantation.
  • Examine the use of rodent, porcine, and non-human primate models for training purposes.
  • Evaluate the integration of contemporary simulation technologies in training curricula.
  • Animal models provide realistic physiological conditions for practicing liver transplantation techniques.
  • The study outlines specific training objectives and assessment tools associated with each animal model.
  • A unified, hybrid training architecture is proposed to improve skill acquisition and ethical governance.

Abstract

Liver transplantation (LTx) is among the most technically challenging procedures in abdominal surgery, especially for patients with severe liver fibrosis and cirrhosis. Constraints in surgical exposure, ethical considerations, and patient safety requirements have expedited the implementation of structured, competency-based training programs. Experimental animal models are crucial for advanced transplant training, offering physiological realism, procedural practice, and translational understanding of surgical problems associated with fibrosis. This narrative review critically synthesizes material from 1990 to 2024 sourced from PubMed/MEDLINE, Scopus, and Google Scholar, concentrating on the pedagogical utilization of rodent, porcine, and non-human primate models. We explicitly associate each model with specified training objectives, evaluative assessment instruments, and the incorporation of contemporary simulation technologies. The review additionally contrasts global training norms and suggests a unified, hybrid architecture to enhance skill acquisition, ethical governance, and patient outcomes.

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Cite This Study

El-Shobari et al. (2026) studied this question.

synapsesocial.com/papers/69a288590a974eb0d3c042bchttps://doi.org/10.3390/biomedicines14030533
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