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March 1, 20260 citations

Accumulated dose on daily iCBCT for rectal cancer: Effects of inter-fraction bowel cavity motion volume.

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HZHongwei ZengEXE XiangyuSZSu Zeng

Key Points

  • This research aims to assess the impact of inter-fraction bowel cavity motion on accumulated doses during radiotherapy for rectal cancer.
  • Conducted daily image-guided cone beam computed tomography (iCBCT) for dose accumulation analysis.
  • Evaluated inter-fraction bowel cavity motion volume's role in dose delivery.
  • Compared accumulated dose metrics with target coverage effectiveness.
  • Identified inter-fraction bowel cavity motion volume as a key factor in escalating doses to the planning target volume (PTV).
  • Accumulated WB V45 serves as a potential marker for monitoring treatment and guiding interventions.
  • Maintained near-minimum target coverage despite increased dose escalation.

Abstract

Daily iCBCT-based dose accumulation identifies inter-fraction BC motion volume as a selective driver of high-dose escalation to the PTV and WB while largely preserving near-minimum target coverage. Accumulated WB V45 may serve as a practical, delivery-based marker for on-treatment surveillance and risk-adapted intervention, complementing plan-based evaluation in rectal cancer radiotherapy.

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Cite This Study

Zeng et al. (2026) studied this question.

synapsesocial.com/papers/69a3d800ec16d51705d2e8abhttps://doi.org/10.1002/acm2.70524
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