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March 1, 20260 citations

Bright Ferritin for Non-Invasive MRI Monitoring of the Fate of Transplanted hPSC-Cardiomyocytes in the Infarcted Rat Heart.

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KZKeyu ZhuangFAFaisal J. AlibhaiBQBeiping Qiang

Key Result

Bright ferritin MRI enables longitudinal, non-invasive imaging of viable transplanted hPSC-cardiomyocytes in healthy and infarcted rat hearts.

Key Points

  • This research aims to evaluate the use of bright ferritin MRI for non-invasive monitoring of transplanted cardiomyocytes in an infarcted heart model.
  • Utilized bright ferritin MRI for imaging
  • Involved transplanted hPSC-cardiomyocytes in rat hearts
  • Conducted longitudinal assessments to track cell distribution
  • Demonstrated effective tracking of viable transplanted hPSC-CMs
  • Showed successful imaging in both healthy and infarcted hearts
  • Enabled on-demand monitoring during the study period

Structured PICO

Does bright ferritin MRI allow non-invasive monitoring of transplanted hPSC-cardiomyocytes in infarcted rat hearts?

P
Population
Healthy and infarcted rat heart models
I
Intervention
Bright ferritin MRI for monitoring transplanted human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs)
O
Outcome
Distribution of viable transplanted hPSC-CMssurrogate

Bright ferritin MRI provides a non-invasive method to longitudinally track the viability and distribution of transplanted human pluripotent stem cell-derived cardiomyocytes in preclinical models.

Abstract

Bright ferritin MRI allows longitudinal, non-invasive, and on-demand imaging of the distribution of viable transplanted hPSC-CMs in the healthy and infarcted rat heart.

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Cite This Study

Zhuang et al. (2026) studied this question. Bright ferritin MRI enables longitudinal, non-invasive imaging of viable transplanted hPSC-cardiomyocytes in healthy and infarcted rat hearts.

synapsesocial.com/papers/69a3d873ec16d51705d2f55bhttps://doi.org/10.1002/mrm.70316
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