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March 1, 2026Skin Pharmacology and Physiology

Monocentric, vehicle-controlled, double-blind study to assess the short- and long-term effects of a Ceramide NP C15-containing emollient on the skin microbiome and the skin barrier function in sensitive skin

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Authors

FDFlorian DimmersDRDoreen ReichertTNThach Ngoc Nguyen

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Overview

Randomized controlled trial assesses ceramide emollient's impact on skin barrier and microbiome in sensitive skin, suggesting clinical relevance.

Key Points

  • The aim is to evaluate the effects of a Ceramide NP C15 emollient on skin barrier function and microbiome in individuals with sensitive skin.
  • Randomized, double-blind, vehicle-controlled trial
  • Fifty participants applied products in a split-body design for six weeks
  • Primary assessments included skin physiology and symptom burden
  • Skin microbiota changes were analyzed using flow cytometry and 16S rRNA gene sequencing
  • Both emollients improved subjective skin symptoms
  • The ceramide formulation significantly reduced transepidermal water loss in participants with impaired skin barrier
  • Microbiota analyses showed modest treatment-associated changes including increased microbial evenness
  • There was a significant enrichment of Bifidobacterium in response to ceramide treatment

Cite This Study

Dimmers et al. (2026) studied this question.

synapsesocial.com/papers/69a3d8a7ec16d51705d2fa50https://doi.org/10.1159/000551043
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