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March 1, 20261 citations

Single-cell RNA sequencing analysis of bone cancer pain model induced by Lewis lung cancer cells in male mice.

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QZQin ZhouXuzhou Medical CollegeJCJiahui ChenXuzhou Medical CollegeHWHao WangGeneral Cardiology

Key Points

  • The research aims to investigate the molecular changes associated with bone cancer pain (BCP) induced by Lewis lung cancer cells.
  • Utilized single-cell RNA sequencing to analyze cellular changes.
  • Induced bone cancer pain in male mice using Lewis lung cancer cells.
  • Assessed molecular mechanism alterations related to pain sensations.
  • Identified key molecular changes associated with BCP.
  • Provided insights into potential therapeutic targets for treatment methods.
  • Demonstrated the impact of tumor cells on pain perception at the cellular level.

Abstract

These data help to understand the molecular mechanism changes caused by BCP and contribute to the development of new treatment methods.

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Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/69a3d8a7ec16d51705d2fa56https://doi.org/10.1080/07853890.2026.2636340
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A pan-cancer single-cell transcriptomic atlas of human bone metastases2026 · 3 citations
  2. 2Analysis of Ionomic Profiles of Spinal Cords in a Rat Model with Bone Cancer Pain2024 · 2 citations
  3. 3Novel therapies for cancer-induced bone pain2024 · 1 citations
  4. 4Characterization of commercially available murine fibrosarcoma NCTC-2472 cells both in vitro and as a model of bone cancer pain in vivo2024
  5. 5Comparative Study of Single-Cell and Bulk RNA Sequencing Data from Metastatic Bone Marrow Neuroblastoma Samples2026