Three intra-articular injections of allogeneic umbilical cord-derived mesenchymal stromal cells in knee osteoarthritis: a phase-I clinical trial.

Key Points

• The primary aim is to evaluate the safety and efficacy of allogeneic umbilical cord-derived mesenchymal stromal cells in treating knee osteoarthritis.
• Conducted a phase-I clinical trial with participants with knee osteoarthritis.
• Administered three intra-articular injections of the cells.
• Monitored safety and effectiveness outcomes over a specified period.
• Demonstrated a favorable safety profile with minimal adverse effects.
• Observed improvements in pain and function among participants.
• Results suggest potential benefits for knee osteoarthritis treatment.