PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 2, 2026Stem Cell Reports1 citationsOpen Access

What we thought we knew about TNF—And what we now must re-learn

View Full Paper
ANAlexandra Rundberg Nilsson

Key Points

  • The aim is to reassess the role of TNF in hematopoiesis and its impact on hematopoietic stem cells.
  • Examined TNF's effects on various cell types and contexts
  • Analyzed its influence on hematopoietic stem cell behavior
  • Investigated the temporal dynamics of TNF's action
  • TNF can suppress but also reprogram hematopoietic stem cells
  • The effects of TNF are context and time-dependent
  • Long-term regenerative capacity of stem cells is not compromised

Abstract

Tumor necrosis factor (TNF) was long cast as a hematopoiesis villain, driving bone marrow and hematopoietic stem cell (HSC) suppression. We now see that TNF's effects are cell type-, context-, and time-dependent. Rather than being simply "bad," TNF can prune progenitors while transiently reprogramming HSCs without sacrificing long-term regenerative capacity.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Alexandra Rundberg Nilsson (2026) studied this question.

synapsesocial.com/papers/69a528b3f1e85e5c73bf0300https://doi.org/10.1016/j.stemcr.2026.102827
Ask AI
Helpful
Bookmark
Share
View Full Paper