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March 2, 20260 citations

Olanzapine Attenuates the Morphine-Induced Conditioned Place Preference: The Involvement of the D2-Like Dopamine Receptors.

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FFFarkhondeh Rzazzaghi- FirozjaeiAPAmineh Sadat Zahiri- PourGGGholamreza Ghavipanjeh

Key Points

  • To investigate the effects of olanzapine on morphine-induced conditioned place preference (CPP) and its interaction with D2-like dopamine receptors.
  • Utilized an animal model to assess morphine-induced CPP.
  • Administered olanzapine to evaluate its influence on CPP behavior.
  • Monitored general locomotor function to ensure it remained unaffected during the assessment.
  • Olanzapine significantly reduced the expression of morphine-induced CPP.
  • D2 receptor expression in the hippocampus was downregulated by olanzapine treatment.
  • General locomotor function was not negatively impacted by olanzapine administration.

Abstract

OLZ attenuates morphine-induced CPP and downregulates D2R expression in the HIP without affecting general locomotor function. These findings suggest a potential therapeutic role for OLZ in the management of opioid-related behaviors. Further research is needed to determine its clinical relevance.

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Cite This Study

Firozjaei et al. (2026) studied this question.

synapsesocial.com/papers/69a52d9af1e85e5c73bf0999https://doi.org/10.1002/brb3.71289
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