Dynamics of memory retrieval in health and diseases

Key Points

• This research investigates how factors like context and stress impact memory retrieval through dynamic access to engrams.
• Analyzed the influence of contextual and psychological factors on engram activation and memory retrieval processes.
• Examined how external stressors affect the transition of engrams to silent states.
• Investigated the role of metabolic hormones and brain activity in modulating memory retrieval efficiency.
• Increased contextual and mood alignment enhances engram reactivation, improving memory recall.
• Social stress can temporarily shift engrams into silent states, hindering memory retrieval.
• Reduced arousal weakens suppression of irrelevant representations by the prefrontal cortex, affecting memory access.