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March 3, 2026Nature Immunology16 citationsOpen Access

Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases

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RHRyan HobsonColumbia University Irving Medical CenterSLSamuel H. S. LevyColumbia University Irving Medical CenterCSChitra Mohinder Singh Singal

Key Points

  • Clonal CD8+ T cells significantly populate the leptomeninges, playing a key role in immune coordination.
  • This research focuses on degenerative brain diseases, revealing interactions with other immune cells.
  • Analysis involves tissue samples from human subjects, examining the immune cell landscape in the leptomeninges.
  • The findings highlight potential avenues for targeted therapies in managing degenerative brain diseases.
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Cite This Study

Hobson et al. (2026) studied this question.

synapsesocial.com/papers/69a75a55c6e9836116a2005ahttps://doi.org/10.1038/s41590-025-02401-6
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