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March 3, 2026Biochimica et Biophysica Acta (BBA) - General Subjects0 citations

Obese serum factors aggravate DNA damage, alter DNA damage response, and promote proliferation in colon cancer cells

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BDBhavana DeshmukhNational Centre for Cell ScienceHYHimanshi YaduvanshiNational Centre for Cell ScienceFBFiroz Khan Bhati

Key Points

  • Increased proliferation was observed in colon cancer cells exposed to obese serum factors, indicating a potential risk for aggressive tumor growth.
  • The study found a significant relationship between DNA damage levels and the presence of obese serum factors, highlighting a critical area for intervention.
  • Analysis of the DNA damage response showed alterations in cellular mechanisms, providing insight into how obesity may influence cancer biology.
  • The findings suggest a complex interplay between obesity-related factors and cancer cell behavior, emphasizing the need for further research on therapeutic strategies.
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Cite This Study

Deshmukh et al. (2026) studied this question.

synapsesocial.com/papers/69a75a69c6e9836116a202e2https://doi.org/10.1016/j.bbagen.2026.130911
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