Epitranscriptomic regulation of NVP-BEZ235 resistance in ccRCC via the YTHDF3-SYNM regulatory pathway

Key Points

• Resistance to NVP-BEZ235 in ccRCC is linked to the YTHDF3-SYNM regulatory pathway, revealing a novel mechanism.
• Key evidence shows that altered activity of YTHDF3 significantly influences SYNM expression and treatment outcomes.
• Analysis of transcriptomic profiles highlights the crucial role of epitranscriptomic changes in drug resistance mechanisms.
• Findings suggest that understanding this regulatory pathway may enable the development of targeted therapies against drug resistance.