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March 3, 2026Frontiers in Immunology0 citationsOpen Access

Role of cytokine levels in pathogen classification and prognosis of pediatric septic shock

GDGuangyan DuHHHaixin HuangRZRuichen Zhang

Key Points

  • Elevated levels of IL-6 and IL-10 predict 28-day mortality in pediatric septic shock patients, aiding in early intervention.
  • Specific elevation of IFN-γ and TNF-α levels also correlates with increased 28-day mortality risk.
  • Independent risk factor analysis confirms IL-6 as a critical marker for predicting adverse outcomes in affected children.
  • Findings suggest a need for enhanced monitoring and potential targeted therapies based on cytokine profiles.

Abstract

Elevated IL-6 and IL-10 levels are valuable for predicting 28-day mortality and identifying gram-negative bacteremia in pediatric patients with septic shock. IFN-γ and TNF-α levels also have significant value for predicting 28-day mortality. Moreover, the IL-6 level was an independent risk factor for 28-day mortality.

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Cite This Study

Du et al. (2026) studied this question.

synapsesocial.com/papers/69a75ad8c6e9836116a21338https://doi.org/10.3389/fimmu.2026.1714948
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