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March 3, 20260 citationsOpen Access

Regulation of Colonic Macrophages and Type-17 and Regulatory T Cells in DSS-Colitis by Ibd-Associated Transcription Factor, Crem

SSShelby L. SchenckMUMd Jashim UddinCPChristopher F. Pastore

Key Points

  • CREM deletion reduced the severity of DSS colitis, enhancing colonic macrophages and RORγt+ T cells.
  • The analysis showed that increases in regulatory T cells and Th17 cells are linked to reduced colitis severity.
  • Investigation of CREM's role was conducted using a model of DSS colitis to examine its impact on immune cells.
  • This study highlights the potential of targeting CREM to manage intestinal inflammation in IBD.

Abstract

Inducible global deletion of Crem reduced the severity of DSS colitis while increasing colonic macrophages, RORγt+ regulatory (pTregs) and T helper (Th17) cells. Future work will investigate the aforementioned cell types to determine the mechanism by which CREM aggravates DSS-colitis, thereby defining the immunoregulatory role of CREM in intestinal inflammation with the goal of identifying new therapeutic targets for IBD.

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Cite This Study

Schenck et al. (2026) studied this question.

synapsesocial.com/papers/69a75ae3c6e9836116a21512https://doi.org/10.64898/2026.01.26.701728
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