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March 3, 2026Anais Brasileiros de Dermatologia0 citationsOpen Access

Diagnostic value of direct immunofluorescence in oral mucous membrane pemphigoid: a retrospective study

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HJHongjie JiangPWPan WeiZXZhixiu Xu

Key Points

  • Direct immunofluorescence is 100% specific, aiding in the diagnosis of mucous membrane pemphigoid.
  • C3 and IgG linear basal membrane zone deposition significantly contribute to diagnostic accuracy.
  • Correlations were observed linking IgM positivity with a longer disease duration in patients.
  • Histopathology and direct immunofluorescence together enhance understanding of disease progression.

Abstract

DIF, 100% specific, aids histopathology in MMP diagnosis, especially with C3/IgG linear BMZ deposition. Notably, IgM positivity correlates with prolonged disease duration, suggesting DIF efficiency may link to disease stage.

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Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/69a75b3dc6e9836116a2236chttps://doi.org/10.1016/j.abd.2025.501254
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