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March 3, 2026Journal of Pharmaceutical Analysis0 citationsOpen Access

GSH-triggered release of anabasine in mitochondria for synergistic chemotherapy assisted by OATP transportation

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MZMiao ZhangLWLing-Li WangSCSi-Ling Chen

Key Points

  • Enhanced apoptosis occurs from anabasine release in mitochondria, driving synergistic effects against tumors.
  • The GSH-triggered mechanism allows for targeted drug delivery via OATP transportation in tumor cells.
  • Therapeutic effects are driven by ferritinophagy, indicating mitochondrial engagement in the treatment process.
  • This approach highlights potential for improving chemotherapy outcomes by combining prodrugs with mitochondrial targeting.

Abstract

• A GSH-triggered prodrug targeting tumor cell mitochondria via OATP-mediated uptake. • Release of a parent drug through an GSH-triggered S N Ar mechanism. • Translation of a nicotinic acetylcholine receptor to an antitumor drug. • Anabasine in mitochondria and induce a synergistic ferritinophagy and apoptosis.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69a75bbac6e9836116a2399chttps://doi.org/10.1016/j.jpha.2026.101565
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