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March 3, 2026Brain Pathology0 citationsOpen Access

Immunohistochemistry as a tool for identifying EGFR amplification in CNS tumors

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ATArnault Tauziède‐EspariatMBMary BahFSFarah Sassi

Key Points

  • EGFR immunohistochemistry is highly specific and sensitive for identifying amplification in glioblastoma.
  • Key evidence shows its usage can significantly improve diagnostic accuracy in brain tumors, particularly glioblastoma.
  • Observational analysis across CNS tumor samples revealed the potential of immunohistochemistry as a routine diagnostic tool.
  • This finding highlights the importance of incorporating immunohistochemistry in neuropathology to enhance diagnostic protocols.

Abstract

EGFR gene amplification constitutes a diagnostic hallmark for glioblastoma, IDH-wildtype (GB, IDH-WT). Herein, we demonstrated that EGFR IHC is a highly specific and sensitive biomarker for identifying EGFR amplification and should be part of the neuropathologist's routine panel of antibodies.

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Cite This Study

Tauziède‐Espariat et al. (2026) studied this question.

synapsesocial.com/papers/69a75c2ec6e9836116a24c11https://doi.org/10.1111/bpa.70073
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