Structures of Ostα/β reveal a unique fold and bile acid transport mechanism

Key Points

• Bile acid transport is facilitated through a unique mechanism observed in Ostα/β structures.
• The detailed crystal structure shows a novel fold that differs from known transport proteins.
• Analysis using X-ray crystallography provides insights into the interaction of Ostα/β with bile acids.
• Understanding this mechanism may lead to developments in the treatment of bile acid-related disorders.