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Synapse
March 3, 20260 citationsOpen Access

The adult nasal mucosa is defined by distinct immune profiles that modulate in-vitro SARS-CoV-2 infection.

SGSarah N. GowanlockVLVictor H.K. LamZTZeynep Güneş Tepe

Key Points

  • Healthy adults show a distinct immune profile characterized by an IFN-λ3-dominant state, contributing to resistance against SARS-CoV-2 infection.
  • This study found that a low-inflammatory immune state supports resistance in vitro, demonstrating crucial factors for respiratory virus susceptibility.
  • Assessment of immune profiles in the adult nasal mucosa highlights how they can modulate responses to respiratory pathogens like SARS-CoV-2.
  • Understanding these immune mechanisms may improve the effectiveness of mucosally administered vaccines against respiratory viruses.

Abstract

Healthy adults exhibit distinct nasal immune profiles, with an IFN-λ3-dominant, low-inflammatory state conferring resistance to SARS-CoV-2 in vitro. The nasal immune milieu may influence susceptibility to respiratory viruses and the efficacy of mucosally administered vaccines.

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Cite This Study

Gowanlock et al. (2026) studied this question.

synapsesocial.com/papers/69a75ceec6e9836116a2636chttps://doi.org/10.21203/rs.3.rs-8397474/v1
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