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March 3, 2026Brain and Behavior0 citationsOpen Access

Probing the Influence of Paternal Diet on Offspring Neuroanatomy With Mouse MRI

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EMEmma G. W. McKnightGLGail LeeLYLeonard L.L. Yeo

Key Points

  • Offspring brain structure changes appear linked to maternal consumption rather than paternal diet.
  • Only structural changes resulting from maternal high-fat/high-sugar diet were observed in offspring.
  • Observational analysis using mouse MRI indicates neuroanatomy may be shaped by diet during parental consumption.
  • These findings highlight the importance of maternal dietary choices in influencing offspring brain development.

Abstract

While small structural changes cannot be ruled out, the results suggest that previously observed changes in offspring brain structure attributed to parental consumption of HF/HSS diet (selected to mimic some aspects of the human "Western Diet") require maternal consumption.

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Cite This Study

McKnight et al. (2026) studied this question.

synapsesocial.com/papers/69a75d14c6e9836116a26884https://doi.org/10.1002/brb3.71195
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