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March 3, 2026Medical Hypothesis Discovery & Innovation in Ophthalmology2 citationsOpen Access

Role of reactive oxygen species and oxidative stress in the pathomechanism of glaucoma

NCNicholas T. H. ChanThe University of SydneyUPUshasree PattamattaWestmead Institute for Medical ResearchAWAndrew WhiteThe University of Sydney

Key Points

  • Oxidative stress plays a crucial role in the pathomechanism of glaucoma, unifying various injury theories.
  • Reactive oxygen species are identified as key mediators in glaucoma-related damage and disease progression.
  • Investigation into specific oxidative stress players may uncover novel therapeutic targets for glaucoma management.
  • These findings highlight the potential for new treatment strategies centered around oxidative stress modulation.

Abstract

ROS and oxidative stress are important mediators in the glaucoma pathomechanism. They contribute to and unify the existing theories of mechanical, vascular, and immunological injury in glaucoma. Investigating specific oxidative stress players in the pathomechanism may reveal new therapeutic targets in the treatment of glaucoma.

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Cite This Study

Chan et al. (2025) studied this question.

synapsesocial.com/papers/69a75d4ac6e9836116a2710dhttps://doi.org/10.51329/mehdiophthal1533
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