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March 3, 2026
Differences in hearing across the lifespan in two strains of Alzheimer’s mouse models as measured using behavioral and physiological techniques
PC
Payton E. Charlton
KB
Kali Burke
Johns Hopkins University
SA
Sevda Abdavinejad
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Key Points
Hearing differences were observed across the lifespan, indicating significant variations in auditory function.
In one mouse model, behavioral assessments showed a noticeable decline in hearing by 30% in older mice compared to younger ones.
This observational analysis utilized both behavioral and physiological techniques to measure hearing ability in the models.
Understanding these strain-specific hearing differences may inform future research on auditory function in Alzheimer's disease.
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Charlton et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75d6fc6e9836116a277aa
https://doi.org/https://doi.org/10.1016/j.heares.2026.109550
Differences in hearing across the lifespan in two strains of Alzheimer’s mouse models as measured using behavioral and physiological techniques | Synapse