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March 3, 2026Urology1 citations

Homologous Recombination Repair Mutations, Next-generation Sequencing Testing, and Treatment Progression by Race Among Patients With Metastatic Castration-sensitive Prostate Cancer

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MBMehmet A. BilenEmory UniversityNSN. ShoreCarolina Urologic Research CenterSBSabree BurbageJohnson & Johnson (United States)

Key Points

  • Treatment progression varies significantly based on homologous recombination repair mutations and race, indicating potential disparities.
  • Key evidence shows 20% of patients had HRR mutations, and those mutations were linked to treatment responses.
  • Analysis explored next-generation sequencing data to assess the impact of genetic mutations on treatment outcomes.
  • Highlighting the need for tailored approaches in managing prostate cancer treatment, especially in racially diverse populations.
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Cite This Study

Bilen et al. (2026) studied this question.

synapsesocial.com/papers/69a75d7ec6e9836116a2796fhttps://doi.org/10.1016/j.urology.2026.01.024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Real-World Outcomes between Patients with BRCA1/2-Positive and Homologous Recombination Repair-Negative Metastatic Castration-Sensitive Prostate Cancer2025 · 4 citations
  2. 2Comparison of Population Characteristics in Real-World Clinical Oncology Databases in the US: Flatiron Health, SEER, and NPCR2020 · 367 citations
  3. 3Assessment of Changes in Cancer Treatment During the First Year of the COVID-19 Pandemic in the US2023 · 18 citations
  4. 4Clinical actionability and utilization of next-generation sequencing for prostate cancer in a changing treatment landscape2022 · 6 citations
  5. 5Advancing health equity in the aftermath of COVID-19: Confronting intensifying racial disparities2024 · 10 citations