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March 3, 2026Journal of Pediatric Surgery0 citations

Short-chain fructooligosaccharides protect against intestinal injury in NEC by restoring AKT/GSK-3β signaling

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YHYingying HuangChildren's Hospital of Fudan UniversityBZBo ZhangUniversity of Science and Technology of ChinaRWRichard Y. WuHospital for Sick Children

Key Points

  • Intestinal injury is reduced by short-chain fructooligosaccharides, highlighting their protective potential.
  • Key evidence shows that treatment with fructooligosaccharides restores AKT/GSK-3β signaling in neonatal models.
  • Analysis of signaling pathways activation demonstrates the role of fructooligosaccharides in protecting gut health.
  • Results indicate significant implications for NEC management in neonatal intensive care settings.
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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69a75de2c6e9836116a282a0https://doi.org/10.1016/j.jpedsurg.2026.162963
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