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March 3, 20260 citationsOpen Access

Single cell profiling reveals GSM-15606 attenuates air pollution-induced inflammation and preserves hippocampal neurogenesis

MSMohammad ShariqUniversity of Southern CaliforniaWPWanqing PanUniversity of Southern CaliforniaXCXiran ChenUniversity of Southern California

Key Points

  • Air pollution activates inflammatory pathways, hindering neurogenesis in the hippocampus, which affects cognitive abilities.
  • GSM-15606 reverses inflammation in glial cells without affecting neural stem cells, indicating targeted cellular effects.
  • Analysis of the protective role of GSM-15606 against pollution-induced damage reveals potential for therapeutic interventions.
  • This approach highlights the importance of specific cellular mechanisms, though it requires further validation in clinical settings.

Abstract

AirPoll activates divergent inflammatory pathways across hippocampal cell populations and suppresses neurogenesis. Targeting inflammation with GSM-15606 selectively reverses glial but not neural stem cell responses, highlighting cell-type-specific mechanisms and potential therapeutic pathways to mitigate pollution-related cognitive vulnerability. These results support GSM-15606 as a protective agent against AirPoll-induced hippocampal dysfunction and amyloidogenic stress.

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Cite This Study

Shariq et al. (2026) studied this question.

synapsesocial.com/papers/69a75e88c6e9836116a29366https://doi.org/10.64898/2026.01.27.702094
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